Yotsuba's daily life is full of adventure. She is energetic, curious, and a bit odd—odd enough to be called strange by her father as well as ignorant of many things that even a five-year-old should know. Because of this, the most ordinary experience can become an adventure for her. As the days progress, she makes new friends and shows those around her that every day can be enjoyable.

ちょっと変わった５歳の女の子「よつば」と、とーちゃんのふたり暮らしを中心に、まわりの人たちとの何気ない日常を描いた作品。　だいたい１日１話のペースで、物語はゆっくりと進みます。