I forgot Niguredou was the same size as Mieruko's younger brother, so it makes sense that his clothes would fit her. BUT IT'S JUST SO HILARIOUS TO SEE HAHAHAHAH
Perhaps the sister isn't a sis-con. Maybe she knows how her sister is. What if her sister has become obsessed before and that person disappeared, so she is trying to prevent that by keeping an eye on her? (Pure speculation.)